Published in ‘Nature Reviews Rheumatology’
1 January 2011, Authors: van Venrooij, Walther J., van Beers, Joyce J.B.C. and Pruijn, Ger J.M.
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Anti-citrullinated peptide antibodies (ACPA) are an important feature of rheumatoid arthritis (RA), and the presence of these autoantibodies is associated with a more-erosive disease course. In this Review, the authors provide an overview of the discovery and development of ACPA as a biomarker in RA, and discuss the future research directions that might further enhance its clinical utility.