Anti-CCP antibodies: the past, the present and the future

Published in ‘Nature Reviews Rheumatology’

1 January 2011, Authors: van Venrooij, Walther J., van Beers, Joyce J.B.C. and Pruijn, Ger J.M.

Read the full article

Read the full article in Nature Reviews Rheumatology.

Abstract

Anti-citrullinated peptide antibodies (ACPA) are an important feature of rheumatoid arthritis (RA), and the presence of these autoantibodies is associated with a more-erosive disease course. In this Review, the authors provide an overview of the discovery and development of ACPA as a biomarker in RA, and discuss the future research directions that might further enhance its clinical utility.